Glucagon polyclonal, anti-pig, human, rat, mouse

Quantity: 100 µl

Background:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Synonyms:
GCG, GLP1, GLP2, GRPP

Isotype: Rabbit Polyclonal

Immunogen:
Porcine pancreatic glucagon/BSA

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody is specific to pancreatic glucagon.

Reactivity: pig, human, rat, mouse

Applications: Immunohistochemistry of frozen and paraffin- embedded sections; no proteolytic treatment required

Working DIlution: 1:25 to 1:50 for immunohistochemistry

Positive Control:
Pancreas

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Mulder H et al. (1995) Diabetologia 38: 395-402
- Stridsberg M et al. (1995) Regul Pept 55: 119-131
- Larsson L et al. (1990) Virchows Arch A Pathol Anat 416: 465-472
- Bottcher G et al. (1989) Pancreas 9 (4): 469-474
- Alumets J et al. (1983) Ultrastructural Pathol 5: 55-72