Glucocorticoid Receptor Polyclonal Antibody

Background:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
GCCR, GCR, GCR, GCRST, glucocorticoid nuclear receptor variant 1, Glucocorticoid receptor, GR, GRL, Grl1, nr3c1, Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Immunogen: Recombinant proteincorresponding to Mouse Glucocorticoid receptor

Swissprot: P04150,P06536,P06537

Calculated MW: 91 kDa
Observed MW: 91 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 1.3 mg/mL
Dilution: WB 1:500-1:1000, IHC 1:500-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.