Glucose Transporter GLUT4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Facilitated glucose transport by mammalian cells is not a property of a single protein but an activity associated with a family of structurally related proteins. Glucose transporter 4 is a insulin-responsive glucose transporter. It belongs to solute carrier family 2, member 1. Insulin alters the subcellular localization of GLUT4 vesicles in human muscle, and that this effect is impaired equally in insulin-resistant subjects with and without diabetes. A similar pattern of defects cause insulin resistance in human adipocytes.Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.

Description:
Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
insulin-responsive antibody, Glucose transporter GLUT 4 antibody, Glucose transporter type 4 antibody, Glucose transporter type 4 insulin responsive antibody, GLUT 4 antibody, GLUT-4 antibody, GLUT4 antibody, GTR4_HUMAN antibody, kug antibody, SLC 2A4 antibody, SLC2A4 antibody, solute carrier family 2(facilitated glucose transporter) member 4 antibody, Solute carrier family 2, facilitated glucose transporter member 4 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Glucose Transporter GLUT4(491-509aa EQEVKPSTELEYLGPDEND), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.