GluR-δ2 Polyclonal Antibody

Background:
glutamate ionotropic receptor delta type subunit 2(GRID2) Homo sapiens The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this

Alternative Names:
GRID2, GLURD2, Glutamate receptor delta-2 subunit, GluR delta-2 subunit

Immunogen: The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 113

GeneID: GRID2

Storage: -20°C/1 year

NOTE: For Research Use Only