GluR1 (Phospho-S845) polyclonal, anti-human, mouse, rat

Background:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.

Alternative Name:
GluR-1, GluA1, GRIA1, GLUR 1, GLUR A, AMPA 1, AMPA selective glutamate receptor 1, AMPA-selective glutamate receptor 1, GluA1, GLUH1, GluR K1, GluR-1, GluR-A, GluR-K1, GLUR1, GLURA, GluRK1, Glutamate receptor 1, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic, Glutamate receptor, ionotropic, AMPA 1, Gria1, GRIA1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243,

Application Dilution:
WB:1:500
FC:1:10-1:50

Specificity: GluR1 (Phospho-S845) polyclonal antibody detects endogenous levels of GluR1 protein only when phosphorylated at S845.

Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Ser845 of human GluR1.

MW: 102 kDa

Swiss-Prot: P42261(Human) P23818(Mouse) P19490(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.