GLUT3 polyclonal, anti-human, mouse, rat

Background:
Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. Glut1, Glut3 and Glut4 are high-affinity transporters, whereas Glut2 is a low-affinity transporter. In adipose and muscle tissue, Insulin stimulates a rapid and dramatic increase in glucose uptake, largely due to the redistribution of the Insulin-inducible glucose transporter, Glut4. In response to Insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to Insulin. Glut2 expression is seen in pancreatic b cells, hepatocytes and basolateral membranes of intestinal and epithelial cells, while the highest expression of Glut3 has been found in neuronal tissue.

Alternative Name:
GLUT-3, SLC2A3, GLUT3, brain, FLJ90380, Glucose transporter type 3, Glucose transporter type 3 brain, GLUT 3, GLUT-3, GLUT3, GTR3, Slc2a3, Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3, Solute carrier family 2, facilitated glucose transporter member 3,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: GLUT3 polyclonal antibody detects endogenous levels of GLUT3 protein.

Immunogen:
recombinant protein

MW: 54 kDa

Swiss-Prot: P11169(Human) P32037(Mouse) Q07647(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.