Glycine Receptor polyclonal, anti-human, mouse, rat, bovine

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems, Signaling Molecules and Interaction

Description:
Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. This antibody detects the 48-kDa alpha-1 and alpha-2 subunits of the glycine receptor.

Alternate Names: Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, Glra1, Glyr

Application Notes: E: 1:500-1:1,000; WB: 1:1,000; IHC: 1:1,000

Accession No.: P07727

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of rat glycine receptor alpha-1 subunit.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.