GNA11 polyclonal, anti-human, mouse

Background:
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).

Alternative Name:
G alpha-11, G-protein subunit alpha-11, GA11, GNA11, GNA11_HUMAN, guanine nucleotide binding protein (G protein), alpha 11 (Gq class), Guanine nucleotide-binding protein G(y) subunit alpha, Guanine nucleotide-binding protein subunit alpha-11, guanine nucleotide-binding protein, alpha 11, guanine nucleotide-binding protein, Gq class, GNA11,

Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200

Specificity: GNA11 polyclonal antibody detects endogenous levels of GNA11 protein.

Immunogen:
Recombinant full length Human GNA11.

MW: ~42 kDa

Swis Prot.: P29992

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.