GNAS monoclonal (Ascites), anti-mouse

Background:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Other Names:
GNAS complex locus;GNAS;

Target/Specificity:
This GNAS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS.

Antigen Region:
287-315

Antigen Type: Synthetic Peptide

Gene Name: GNAS {ECO:0000313|EMBL:AAH89157.2}
Gene ID: 2778
Primary Accession: Q5FWY2
Other Accession: P29797; Q8R4A8; P63095; P63094; P63092; P04896; Q63803; Q6R0H7; Q5JWF2
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.