GNAS polyclonal, anti-human

Background:
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2.

Synonyms: GNAS1, GSP, Adenylate cyclase-stimulating G alpha protein

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human GNAS

Gene Symbol: GNAS

Gene ID: 2778

Swiss prot: P63092

Calculated MW: 46/44/111/78/28kDa

Recommended dilution:
WB 1:5000-8000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.