GNAS polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP13065b
Catalog Number: AC-AP13065b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33001
Applications: WB, IF, FC, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33001
Applications: WB, IF, FC, IHC-P
Datasheet
Request Information
Background:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Other Names:
GNAS
Target/Specificity:
This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS.
Antigen Region:
287-315
Antigen Type: Synthetic Peptide
Gene Name: GNAS {ECO:0000313|EMBL:AAH89157.2}
Gene ID: 2778
Primary Accession: Q5FWY2
Other Accession: P29797; Q8R4A8; P63095; P63094; P63092; P04896; Q63803; Q6R0H7; Q5JWF2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
Other Names:
GNAS
Target/Specificity:
This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS.
Antigen Region:
287-315
Antigen Type: Synthetic Peptide
Gene Name: GNAS {ECO:0000313|EMBL:AAH89157.2}
Gene ID: 2778
Primary Accession: Q5FWY2
Other Accession: P29797; Q8R4A8; P63095; P63094; P63092; P04896; Q63803; Q6R0H7; Q5JWF2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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