GNAT1 Polyclonal Antibody

Background:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified.GNAT1 (G Protein Subunit Alpha Transducin 1) is a Protein Coding gene. Diseases associated with GNAT1 include Night Blindness, Congenital Stationary, Autosomal Dominant 3 and Night Blindness, Congenital Stationary, Type 1G. Among its related pathways are Phospholipase-C Pathway and Phototransduction. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is GNAT2.

Research Area: Cancer, Neuroscience, Signal Transduction

Synonyms:
CSNBAD3, GBT1, GNAT1, GNAT1, GNATR, guanine nucleotide binding protein (G protein) alpha transducing activity polypeptide 1, guanine nucleotide binding protein G(T) alpha 1 subunit, Guanine nucleotide-binding protein G(t) subunit alpha-1, Rod specific transducin, rod-type transducin alpha subunit, Transducin alpha-1 chain, transducin, rod-specific

Immunogen: Synthetic peptide of human GNAT1

Swissprot: P11488
Gene Accession: NP000163

Calculated MW: 40 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.72 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.