GNB3 antibody (clone M1-1-1D5), anti-human
€435.00
In stock
SKU
AC-AT2228a
Catalog Number: AC-AT2228a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
Request Information AC-AT2228a">Request Information
Background:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
Other Names:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, Transducin beta chain 3, GNB3
Antigen Type:
Recombinant Protein
Gene Name: GNB3
Gene ID: 2784
NCBI Accession: NP_002066.1
Primary Accession: P16520
Other Accession: BC002454
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
Other Names:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, Transducin beta chain 3, GNB3
Antigen Type:
Recombinant Protein
Gene Name: GNB3
Gene ID: 2784
NCBI Accession: NP_002066.1
Primary Accession: P16520
Other Accession: BC002454
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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