GNRHR Polyclonal Antibody

Background:
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Research Area: Cancer, Neuroscience

Synonyms:
GnRH receptor, GnRH-R, GNRHR, GNRHR, GNRHR1, Gonadotropin releasing hormone receptor, gonadotropin-releasing hormone (type 1) receptor 1, Gonadotropin-releasing hormone receptor, GRHR, HH7, leutinizing-releasing hormone receptor, lh-rh, LHRHR, LRHR, luliberin receptor, luteinizing hormone releasing hormone receptor, type I GnRH receptor

Immunogen: Synthetic peptide of human GNRHR

Swissprot: P30968
Gene Accession: NP_000397

Calculated MW: 28 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:2000-1:5000, IHC 1:150-1:500

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8681/sc-8682/sc-13944