GP1BA antibody (clone 1C6), anti-human
€435.00
In stock
SKU
AC-AT2241a
Catalog Number: AC-AT2241a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP, E
Request Information AC-AT2241a">Request Information
Background:
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Other Names:
Platelet glycoprotein Ib alpha chain, GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Antigen CD42b-alpha, CD42b, Glycocalicin, GP1BA
Antigen Type:
Recombinant Protein
Gene Name: GP1BA
Gene ID: 2811
Primary Accession: P07359
Other Accession: BC027955
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Other Names:
Platelet glycoprotein Ib alpha chain, GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Antigen CD42b-alpha, CD42b, Glycocalicin, GP1BA
Antigen Type:
Recombinant Protein
Gene Name: GP1BA
Gene ID: 2811
Primary Accession: P07359
Other Accession: BC027955
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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