GP6 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP5691b
Catalog Number: AC-AP5691b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22884
Applications: FC, WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22884
Applications: FC, WB, IHC-P
Datasheet
Request Information
Background:
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).
Other Names:
Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6
Target/Specificity:
This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6.
Antigen Region:
309-337
Antigen Type: Synthetic Peptide
Gene Name: GP6 (HGNC:14388)
Gene ID: 51206
Primary Accession: Q9HCN6
NCBI Accession: NP_001242946.1;NP_057447.4
Other Accession: NP_057447.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).
Other Names:
Platelet glycoprotein VI, GPVI, Glycoprotein 6, GP6
Target/Specificity:
This GP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the C-terminal region of human GP6.
Antigen Region:
309-337
Antigen Type: Synthetic Peptide
Gene Name: GP6 (HGNC:14388)
Gene ID: 51206
Primary Accession: Q9HCN6
NCBI Accession: NP_001242946.1;NP_057447.4
Other Accession: NP_057447.4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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