GPC3 polyclonal, anti-human, mouse

Background:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Synonyms: DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1

Cellular Location: Cell membrane Extracellular side GPI-anchor Lipid-anchor Secreted extracellular space

Immunogen:
Recombinant protein of human GPC3

Gene Symbol: GPC3

Gene ID: 2719

Swiss prot: P51654

Calculated MW: 66kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.