GPC3 Polyclonal Antibody

Background:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Developmental Biology, Signal Transduction, Stem Cells

Synonyms:
DGSX, Glypican proteoglycan 3, Glypican-3 [Precursor], Gpc3, GPC3, GTR2 2, GTR2-2, Heparan sulphate proteoglycan, Intestinal protein OCI 5, Intestinal protein OCI-5, MXR7, OCI 5, OCI-5, OCI5, SDYS, Secreted glypican-3, SGB, SGBS, SGBS1

Immunogen: Synthetic peptide of human GPC3

Swissprot: P51654
Gene Accession: NP004475

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.8 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.