GPI polyclonal, anti-human

Background:
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.

Synonyms: AMF, GNPI, NLK, PGI, PHI, SA-36, SA36, glucose-6-phosphate isomerase

Cellular Location: Cytoplasm 

Immunogen:
Recombinant protein of human GPI

Gene Symbol: GPI

Gene ID: 2821

Swiss prot: P06744

Calculated MW: 63kDa

Recommended dilution:
WB 1:5000-8000, IHC 1:100-300,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20°C. Avoid freeze / thaw cycles.