GPR143 polyclonal, anti-human
€469.00
In stock
SKU
252189
Protein Family: Receptors and Channels
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction
Description:
G-protein coupled receptor 143 (GPR143) is a receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, GPR143 stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane. This ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. The activity of GPR143 is mediated by G proteins which activate the phosphoinositide signaling pathway. GPR143 also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1), also known as Nettleship-Falls type ocular albinism. This is a form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted.
Alternate Names: G-protein coupled receptor 143, Ocular albinism type 1 protein, GPR143, OA1
Application Notes: E: 1:1,000-1:5,000; WB: 1:200-1:500
Accession No.: P51810
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR143.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction
Description:
G-protein coupled receptor 143 (GPR143) is a receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, GPR143 stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane. This ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. The activity of GPR143 is mediated by G proteins which activate the phosphoinositide signaling pathway. GPR143 also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1), also known as Nettleship-Falls type ocular albinism. This is a form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted.
Alternate Names: G-protein coupled receptor 143, Ocular albinism type 1 protein, GPR143, OA1
Application Notes: E: 1:1,000-1:5,000; WB: 1:200-1:500
Accession No.: P51810
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR143.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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