GPR56 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM8454b
Catalog Number: AC-AM8454b
Size: 80 µl, 400 µl
Isotype: mouse IgG1,k
Clone Name: 1443CT377.65.29
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1,k
Clone Name: 1443CT377.65.29
Applications: WB
Datasheet
Request Information
Background:
Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
Other Names:
G-protein coupled receptor 56, Protein TM7XN1, GPR56 N-terminal fragment, GPR56 NT, GPR56(N), GPR56 extracellular subunit, GPR56 subunit alpha, GPR56 C-terminal fragment, GPR56 CT, GPR56(C), GPR56 seven-transmembrane subunit, GPR56 7TM, GPR56 subunit beta, GPR56, TM7LN4, TM7XN1
Target/Specificity:
This antibody is generated from a mouse immunized with a recombinant protein.
Antigen Region:
Recombinant Protein
Gene Name: ADGRG1 (HGNC:4512)
Gene ID: 9289
Primary Accession: Q9Y653
Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
Other Names:
G-protein coupled receptor 56, Protein TM7XN1, GPR56 N-terminal fragment, GPR56 NT, GPR56(N), GPR56 extracellular subunit, GPR56 subunit alpha, GPR56 C-terminal fragment, GPR56 CT, GPR56(C), GPR56 seven-transmembrane subunit, GPR56 7TM, GPR56 subunit beta, GPR56, TM7LN4, TM7XN1
Target/Specificity:
This antibody is generated from a mouse immunized with a recombinant protein.
Antigen Region:
Recombinant Protein
Gene Name: ADGRG1 (HGNC:4512)
Gene ID: 9289
Primary Accession: Q9Y653
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