GPR75 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5752
Background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR75 is a 540 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR1 family. Highly expressed in spinal cord and brain, GPR75 is also found at low levels in retinal pigment epithelium. The gene encoding GPR75 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome.
Alternative Name:
Probable G-protein coupled receptor 75
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: GPR75 polyclonal antibody detects endogenous levels of GPR75 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 423-468 of Human GPR75.
MW: ~ 59 kDa
Swis Prot.: O95800
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR75 is a 540 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR1 family. Highly expressed in spinal cord and brain, GPR75 is also found at low levels in retinal pigment epithelium. The gene encoding GPR75 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome.
Alternative Name:
Probable G-protein coupled receptor 75
Application Dilution: WB: 1:500~1:1000, ICC: 1:50~1:200
Specificity: GPR75 polyclonal antibody detects endogenous levels of GPR75 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 423-468 of Human GPR75.
MW: ~ 59 kDa
Swis Prot.: O95800
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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