GPS1573 Peptide
€260.00
In stock
SKU
350595
Protein Family: Hormones
Alternate Names: GPS1573; MC2R antagonist; Adrenocorticotropic hormone receptor antagonist
Accession No.: Q01718
Description:
GPS1573 is a newly described potent and dose-dependent peptide antagonist of ACTH-stimulated melanocortin type 2 receptor (MC2R) activity in vitro (IC50 = 66 nM). GPS1573 antagonizes MC4R with IC50 of 950 nM, therefore showing selectivity for MC2R. The binding of ACTH to MC2R regulates steroidogenesis leading to metabolic diseases such as Cushing's disease in patients with pituitary dysfunctions.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1807.0 g/mol
Sequence:
H-Nle-Pro-(D-Phe)-Arg-(D-Trp)-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 or H-Nle-PfRwFKAVGKKRR-NH2
Composition:
C86H139N27O16
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Alternate Names: GPS1573; MC2R antagonist; Adrenocorticotropic hormone receptor antagonist
Accession No.: Q01718
Description:
GPS1573 is a newly described potent and dose-dependent peptide antagonist of ACTH-stimulated melanocortin type 2 receptor (MC2R) activity in vitro (IC50 = 66 nM). GPS1573 antagonizes MC4R with IC50 of 950 nM, therefore showing selectivity for MC2R. The binding of ACTH to MC2R regulates steroidogenesis leading to metabolic diseases such as Cushing's disease in patients with pituitary dysfunctions.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1807.0 g/mol
Sequence:
H-Nle-Pro-(D-Phe)-Arg-(D-Trp)-Phe-Lys-Ala-Val-Gly-Lys-Lys-Arg-Arg-NH2 or H-Nle-PfRwFKAVGKKRR-NH2
Composition:
C86H139N27O16
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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