GPSM2 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Signal transduction

Synonyms:
DFNB82, G protein signalling modulator 2 (AGS3 like C. elegans), G protein signalling modulator 2, G-protein-signaling modulator 2, Gpsm2, GPSM2, HGNC:29501, LGN, LGN protein, Mosaic protein LGN, Pins

Immunogen: Synthetic peptide of human GPSM2

Swissprot: P81274
Gene Accession: NP037428

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.92 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.