GPT2 Polyclonal Antibody

Background:
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Metabolism, Signal transduction

Synonyms:
AAT2, Alanine aminotransferase 2, ALAT2, ALT2, Glutamate pyruvate transaminase 2, Glutamic alanine transaminase 2, Glutamic pyruvate transaminase (alanine aminotransferase) 2, Glutamic pyruvic transaminase 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2, GPT 2, gpt2

Immunogen: Synthetic peptide of human GPT2

Swissprot: Q8TD30
Gene Accession: NP597700

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 2.16 mg/mL
Dilution: IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.