GPX4 polyclonal, anti-human, mouse, rat, zebrafish

Background:
Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1-8). GPx-1, Gpx-2 and Gpx-3 exist as homotetramers. Gpx-4 has a high tendancy to form high molecular weight oligomers.

Alternative Name:
PHGPx, GPx-4, GSHPx-4, Glutathione peroxidase 4, GPX 4, GPX-4, GPX4, GPX4, GSHPx-4, MCSP, mitochondrial, PHGPx, Phospholipid hydroperoxidase, Phospholipid hydroperoxide glutathione peroxidase, Phospholipid hydroperoxide glutathione peroxidase mitochondrial, snGPx, snPHGPx, Sperm nucleus glutathione peroxidase,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200

Specificity: GPX4 polyclonal antibody detects endogenous levels of GPX4 protein.

Immunogen:
Recombinant protein

MW: 22 kDa Clone number: JU11-31

Swiss-Prot: P36969(Human) O70325(Mouse) P36970(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.