Granzyme B polyclonal, anti-human

Quantity: 100 µg

Background:
Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes(CTL) and natural killer(NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are though to protect their host by inducing apoptosis of cells that bear on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Description:
Rabbit IgG polyclonal antibody for Granzyme B (GZMB) detection. Tested with WB in Human.

Synonyms:
C11 antibody, Cathepsin G like 1 antibody, Cathepsin G-like 1 antibody, CCPI antibody, CGL 1 antibody, CGL1 antibody, CSP B antibody, CSPB antibody, CTLA-1 antibody, CTLA1 antibody, CTSGL1 antibody, Cytotoxic serine protease B antibody, Cytotoxic T lymphocyte associated serine esterase 1 antibody, Cytotoxic T lymphocyte proteinase 2 antibody, Cytotoxic T-lymphocyte proteinase 2 antibody, Fragmentin 2 antibody, Fragmentin-2 antibody, GRAB_HUMAN antibody, Granzyme 2 antibody, Granzyme B(granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody, Granzyme B antibody, Granzyme-2 antibody, GranzymeB antibody, GRB antibody, Gzmb antibody, Hlp antibody, Human lymphocyte protein antibody, Lymphocyte protease antibody, Protease, serine, B antibody, SECT antibody, T cell serine protease 1-3E antibody, T-cell serine protease 1-3E antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme B(168-184aa QEDRKCESDLRHYYDST).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.