Granzyme B rabbit polyclonal, anti-human, mouse, rat

Backgroud: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Synonyms: Granzyme B, Cathepsin G-like 1, CTSGL1, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, SECT, GZMB, CGL1, CSPB, CTLA1, GRB

Gene Name: GZMB

Gene ID: 3002

SwissProt ID: P10144

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.