Granzyme M rabbit polyclonal, anti-human, mouse, rat

Backgroud: Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],function:Cleaves peptide substrates after methionine, leucine, and norleucine.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Granules of large granular lymphocytes.,

Synonyms: Granzyme M (EC 3.4.21.-, Met-1 serine protease, Hu-Met-1, Met-ase, Natural killer cell granular protease)

Gene Name: GZMM MET1

Gene ID: 3004

SwissProt ID: P51124

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.