GRB2 (clone 5G3-E7-F11), anti-human, mouse, rat

Background:
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2

Cellular Location: Cytoplasm Endosome Golgi apparatus Nucleus

Immunogen:
Recombinant protein of human GRB2.

Gene Symbol: GRB2

Gene ID: 2885

Swiss prot: P62993

Calculated MW: 25kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.