GRB2 Polyclonal Antibody

Background:
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Signal Transduction

Synonyms:
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2, GRB2

Immunogen: Recombinant fusion protein of human GRB2 (NP_002077.1).

Swissprot: P62993
Gene ID: 2885

Calculated MW: 20 kDa/25 kDa
Observed MW: 33 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.