GRB7 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7805
Background:
Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. GRB7 maps to the region on mouse chromosome 11 containing the Neu gene. This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer. Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185.
Alternative Name:
B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7,
Application Dilution: WB: 1:500 - 1:2000
Specificity: GRB7 polyclonal antibody detects endogenous levels of GRB7 protein.
Immunogen:
Recombinant full length Human GRB7.
MW: ~ 60 kDa
Swis Prot.: Q14451
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. GRB7 maps to the region on mouse chromosome 11 containing the Neu gene. This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer. Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185.
Alternative Name:
B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7,
Application Dilution: WB: 1:500 - 1:2000
Specificity: GRB7 polyclonal antibody detects endogenous levels of GRB7 protein.
Immunogen:
Recombinant full length Human GRB7.
MW: ~ 60 kDa
Swis Prot.: Q14451
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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