GREM1 Polyclonal Antibody

Background:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Signal Transduction, Stem Cells

Synonyms:
BMP antagonist 1, Cell proliferation inducing gene 2 protein, Cell proliferation-inducing gene 2 protein, CKTSF1B1, colorectal adenoma and carcinoma 1, Cysteine knot superfamily 1, Cysteine knot superfamily 1, BMP antagonist 1, Cysteine knot superfamily BMP antagonist 1, DAN domain family member 2, DAND2, Down regulated in Mos-transformed cells protein, Down-regulated in Mos-transformed cells protein, DRM, grem1, GREM1, Gremlin 1 homolog, cysteine knot superfamily, Gremlin 1 like protein, Gremlin 1, cysteine knot superfamily, homolog, GREMLIN, Gremlin-1, Gremlin1, IHG-2, IHG2, Increased in high glucose 2, Increased in high glucose protein 2, PIG2, Proliferation inducing gene 2, proliferation inducing gene 2 protein

Immunogen: Recombinant protein of human GREM1

Swissprot: O60565
Gene Accession: BC069525

Calculated MW: 21 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18274/sc-18276/sc-18275/sc-28873