GREMLIN Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6133a
Background:
Using a Xenopus expression-cloning screen, Gremlin was isolated as an antagonist of bone morphogenetic protein (BMP) signaling that is expressed in the neural crest. Gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. All these family members are secreted proteins that act as BMP antagonists in embryonic explants. The proposed function of Gremlin, Cerberus, and DAN is a BMP signaling blocking activity by binding BMPs, preventing them from interacting with their receptors. Gremlin, Cerberus, and DAN may control diverse processes in growth and development by selectively antagonizing the activities of different subsets of the transforming growth factor (TGF)-beta ligands. By homology searches, Hsu et al. (1998) cloned the human homolog of Xenopus Gremlin. The human gremlin cDNA encodes a predicted 184-amino acid protein.
Other Names:
Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein, Grem1, Cktsf1b1, Drm
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6133a was selected from the C-term region of human GREMLIN . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: Grem1
Gene ID: 23892
Primary Accession: O70326
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Using a Xenopus expression-cloning screen, Gremlin was isolated as an antagonist of bone morphogenetic protein (BMP) signaling that is expressed in the neural crest. Gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. All these family members are secreted proteins that act as BMP antagonists in embryonic explants. The proposed function of Gremlin, Cerberus, and DAN is a BMP signaling blocking activity by binding BMPs, preventing them from interacting with their receptors. Gremlin, Cerberus, and DAN may control diverse processes in growth and development by selectively antagonizing the activities of different subsets of the transforming growth factor (TGF)-beta ligands. By homology searches, Hsu et al. (1998) cloned the human homolog of Xenopus Gremlin. The human gremlin cDNA encodes a predicted 184-amino acid protein.
Other Names:
Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein, Grem1, Cktsf1b1, Drm
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6133a was selected from the C-term region of human GREMLIN . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: Grem1
Gene ID: 23892
Primary Accession: O70326
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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