GRIA4 polyclonal, anti-human, mouse, rat

Background:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

Synonyms: GLUR4, GLUR4C, GLURD, GluA4

Cellular Location: Cell junction Cell membrane Cell projection Multi-pass membrane protein dendrite postsynaptic cell membrane synapse

Immunogen:
Recombinant protein of human GLUR4

Gene Symbol: GRIA4

Gene ID: 2893

Swiss prot: P48058

Calculated MW: 101kDa

Recommended dilution:
WB 1:1000-4000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.