GRID2 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13471b
Background:
Human glutamate receptor delta-2 (GRID2) is a relativelynew member of the family of ionotropic glutamate receptors whichare the predominant excitatory neurotransmitter receptors in themammalian brain. GRID2 is a predicted 1,007 amino acid proteinthat shares 97% identity with the mouse homolog which is expressedselectively in cerebellar Purkinje cells. A point mutation inmouse GRID2, associated with the phenotype named 'lurcher', in theheterozygous state leads to ataxia resulting from selective,cell-autonomous apoptosis of cerebellar Purkinje cells duringpostnatal development. Mice homozygous for this mutation dieshortly after birth from massive loss of mid- and hindbrain neuronsduring late embryogenesis. This strongly suggests a role for GRID2in neuronal apoptotic death.
Other Names:
Glutamate receptor ionotropic, delta-2, GluD2, GluR delta-2 subunit, GRID2, GLURD2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13471b was selected from the C-term region of GRID2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRID2
Gene ID: 2895
Primary Accession: O43424
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Human glutamate receptor delta-2 (GRID2) is a relativelynew member of the family of ionotropic glutamate receptors whichare the predominant excitatory neurotransmitter receptors in themammalian brain. GRID2 is a predicted 1,007 amino acid proteinthat shares 97% identity with the mouse homolog which is expressedselectively in cerebellar Purkinje cells. A point mutation inmouse GRID2, associated with the phenotype named 'lurcher', in theheterozygous state leads to ataxia resulting from selective,cell-autonomous apoptosis of cerebellar Purkinje cells duringpostnatal development. Mice homozygous for this mutation dieshortly after birth from massive loss of mid- and hindbrain neuronsduring late embryogenesis. This strongly suggests a role for GRID2in neuronal apoptotic death.
Other Names:
Glutamate receptor ionotropic, delta-2, GluD2, GluR delta-2 subunit, GRID2, GLURD2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13471b was selected from the C-term region of GRID2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRID2
Gene ID: 2895
Primary Accession: O43424
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review