GRID2 antibody (clone 1A1), anti-human
€435.00
In stock
SKU
AC-AT2263a
Catalog Number: AC-AT2263a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
Request Information AC-AT2263a">Request Information
Background:
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
Other Names:
Glutamate receptor ionotropic, delta-2, GluD2, GluR delta-2 subunit, GRID2, GLURD2
Antigen Type:
Recombinant Protein
Gene Name: GRID2
Gene ID: 2895
NCBI Accession: NP_001501.2
Primary Accession: O43424
Other Accession: NM_001510
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
Other Names:
Glutamate receptor ionotropic, delta-2, GluD2, GluR delta-2 subunit, GRID2, GLURD2
Antigen Type:
Recombinant Protein
Gene Name: GRID2
Gene ID: 2895
NCBI Accession: NP_001501.2
Primary Accession: O43424
Other Accession: NM_001510
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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