GRIN2A polyclonal, anti-mouse, rat

Background:
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

Synonyms: EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A

Cellular Location: Cell junction Cell membrane Multi-pass membrane protein postsynaptic cell membrane synapse

Immunogen:
Recombinant protein of human GRIN2A

Gene Symbol: GRIN2A

Gene ID: 2903

Swiss prot: Q12879

Calculated MW: 165kDa

Recommended dilution:
WB 1:500-1000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.