GRIN2A Polyclonal Antibody

Background:
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Neuroscience

Synonyms:
EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, GRIN2A, NMDA 2A

Immunogen: Recombinant fusion protein of human GRIN2A (NP_000824.1).

Swissprot: Q12879
Gene ID: 2903

Calculated MW: 144 kDa/165 kDa
Observed MW: 200 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.