GRK2 polyclonal, anti-human, mouse, rat

Background:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Synonyms: GRK2, BARK1, BETA-ARK1

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human ADRBK1

Gene Symbol: ADRBK1

Gene ID: 156

Swiss prot: P25098

Calculated MW: 79kDa

Recommended dilution:
IHC 1:100-300

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.