GRM1 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13701b
Background:
L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. The canonical alpha isoform of the metabotropicglutamate receptor 1 gene is a disulfide-linked homodimer whoseactivity is mediated by a G-protein-coupledphosphatidylinositol-calcium second messenger system. Alternativesplicing results in multiple transcript variants encoding distinctisoforms; some of which may have distinct functions. [provided byRefSeq].
Other Names:
Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13701b was selected from the C-term region of GRM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRM1
Gene ID: 2911
Primary Accession: Q13255
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. The canonical alpha isoform of the metabotropicglutamate receptor 1 gene is a disulfide-linked homodimer whoseactivity is mediated by a G-protein-coupledphosphatidylinositol-calcium second messenger system. Alternativesplicing results in multiple transcript variants encoding distinctisoforms; some of which may have distinct functions. [provided byRefSeq].
Other Names:
Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13701b was selected from the C-term region of GRM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRM1
Gene ID: 2911
Primary Accession: Q13255
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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