GRM1 Polyclonal Antibody

Background:
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Neuroscience

Synonyms:
GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13

Immunogen: Recombinant fusion protein of human GRM1 (NP_001264993.1).

Swissprot: Q13255
Gene ID: 2911

Calculated MW: 101 kDa/132 kDa
Observed MW: 132 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.