GRM2 antibody (clone 3H7), anti-human
€435.00
In stock
SKU
AC-AT2264a
Catalog Number: AC-AT2264a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2264a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2264a">Request Information
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
Metabotropic glutamate receptor 2, mGluR2, GRM2, GPRC1B, MGLUR2
Antigen Type:
Recombinant Protein
Gene Name: GRM2 (HGNC:4594)
Gene ID: 2912
NCBI Accession: NP_000830.2;NP_001123535.1
Primary Accession: Q14416
Other Accession: NM_000839
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
Metabotropic glutamate receptor 2, mGluR2, GRM2, GPRC1B, MGLUR2
Antigen Type:
Recombinant Protein
Gene Name: GRM2 (HGNC:4594)
Gene ID: 2912
NCBI Accession: NP_000830.2;NP_001123535.1
Primary Accession: Q14416
Other Accession: NM_000839
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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