GRM2 Polyclonal Antibody

Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Research Area: Neuroscience

Synonyms:
AMPA selective glutamate receptor 2 , GLUR2, GLURB, Glutamate metabotropic receptor 2, Glutamate receptor homolog, Glutamate receptor metabotropic 2, GPRC1B, GRM2, GRM2, Metabotropic glutamate receptor 2, mGlu2, mGluR2, OTTHUMP00000210984, OTTHUMP00000210986

Immunogen: Synthetic peptide of human GRM2

Swissprot: Q14416
Gene Accession: NP000830

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.