GRM6 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP13735c
Catalog Number: AC-AP13735c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33716
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33716
Applications: WB
Datasheet
Request Information
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Other Names:
Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6
Target/Specificity:
This GRM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human GRM6.
Antigen Region:
369-398
Antigen Type: Synthetic Peptide
Gene Name: GRM6
Gene ID: 2916
Primary Accession: O15303
NCBI Accession: NP_000834.2
Other Accession: NP_000834.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Other Names:
Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6
Target/Specificity:
This GRM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human GRM6.
Antigen Region:
369-398
Antigen Type: Synthetic Peptide
Gene Name: GRM6
Gene ID: 2916
Primary Accession: O15303
NCBI Accession: NP_000834.2
Other Accession: NP_000834.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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