GRM7 polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP16975a
Catalog Number: AC-AP16975a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36657
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB36657
Applications: WB
Datasheet
Request Information
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
Target/Specificity:
This GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the N-terminal region of human GRM7.
Antigen Region:
240-269
Antigen Type: Synthetic Peptide
Gene Name: GRM7
Gene ID: 2917
Primary Accession: Q14831
NCBI Accession: NP_000835.1;NP_870989.1
Other Accession: P35400; Q68ED2; NP_000835.1; NP_870989.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
Other Names:
Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
Target/Specificity:
This GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the N-terminal region of human GRM7.
Antigen Region:
240-269
Antigen Type: Synthetic Peptide
Gene Name: GRM7
Gene ID: 2917
Primary Accession: Q14831
NCBI Accession: NP_000835.1;NP_870989.1
Other Accession: P35400; Q68ED2; NP_000835.1; NP_870989.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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