GRM8 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13777b
Background:
L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene. [provided byRefSeq].
Other Names:
Metabotropic glutamate receptor 8, mGluR8, GRM8, GPRC1H, MGLUR8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13777b was selected from the C-term region of GRM8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRM8
Gene ID: 2918
Primary Accession: O00222
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene. [provided byRefSeq].
Other Names:
Metabotropic glutamate receptor 8, mGluR8, GRM8, GPRC1H, MGLUR8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13777b was selected from the C-term region of GRM8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GRM8
Gene ID: 2918
Primary Accession: O00222
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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