GRO alpha polyclonal, anti-human

Quantity: 100 µg

Background:
CXCL1(Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROalpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha(MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated.

Description:
Rabbit IgG polyclonal antibody for Growth-regulated alpha protein (CXCL1) detection. Tested with WB in Human.

Synonyms:
C-X-C motif chemokine 1 antibody, Chemokine(C X C motif) ligand 1 antibody, Chemokine(C-X-C motif) ligand 1(melanoma growth stimulating activity, alpha) antibody, chemokine(C-X-C motif) ligand 1 antibody, Chemokine ligand 1 antibody, CINC-1 antibody, Cxcl 1 antibody, Cxcl1 antibody, Cytokine-induced neutrophil chemoattractant 1 antibody, Fibroblast secretory protein antibody, Fsp antibody, Gro 1 antibody, Gro A antibody, GRO alpha antibody, GRO antibody, GRO protein, alpha antibody, GRO-alpha(1-73) antibody, GRO-alpha(6-73) antibody, Gro1 antibody, GRO1 oncogene(melanoma growth stimulating activity, alpha) antibody, GRO1 oncogene(melanoma growth-stimulating activity) antibody, Gro1 oncogene antibody, GroA antibody, GROA_HUMAN antibody, Growth regulated protein alpha antibody, Growth regulated protein GRO antibody, KC antibody, KC chemokine, mouse, homolog of antibody, Melanoma growth stimulatory activity alpha antibody, Melanoma growth stimulatory activity antibody, Melanoma growth stimulatory activity, alpha antibody, MGSA a antibody, MGSA alpha antibody, MGSA antibody, MGSA-a antibody, N51 antibody, NAP 3 antibody, NAP-3 antibody, NAP3 antibody, Neutrophil activating protein 3 antibody, Neutrophil-activating protein 3 antibody, Platelet-derived growth factor-inducible protein KC antibody, Scyb 1 antibody, SCYB1 antibody, Secretory protein N51 antibody, Small inducible cytokine subfamily B, member 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human GRO alpha(99-107aa KMLNSDKSN).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.