Growth hormone receptor polyclonal, anti-mouse, rat

Quantity: 100 µg

Background:
The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3(d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome, also known as the growth hormone insensitivity syndrome(GHIS).

Description:
Rabbit IgG polyclonal antibody for Growth hormone receptor (GHR) detection. Tested with WB in Mouse, Rat.

Synonyms:
GH receptor antibody, GH-binding protein antibody, GHBP antibody, GHBP, included antibody, GHR antibody, GHR_HUMAN antibody, Growth hormone binding protein antibody, Growth hormone receptor antibody, Growth hormone receptor precursor antibody, Growth hormone-binding protein antibody, Growth hormone-binding protein, included antibody, Increased responsiveness to growth hormone, included antibody, Serum binding protein antibody, Serum-binding protein antibody, Somatotropin receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor(231-247aa DKEHEVRVRSRQRSFEK), identical to the related rat sequence.A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor(231-247aa DKEHEVRVRSRQRSFEK), identical to the related rat sequence.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.