GRPR polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP9790c
Catalog Number: AC-AP9790c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB24634
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB24634
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Other Names:
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
Target/Specificity:
This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.
Antigen Region:
123-152
Antigen Type: Synthetic Peptide
Gene Name: GRPR
Gene ID: 2925
Primary Accession: P30550
NCBI Accession: NP_005305.1
Other Accession: P52500; P21729
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Other Names:
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
Target/Specificity:
This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.
Antigen Region:
123-152
Antigen Type: Synthetic Peptide
Gene Name: GRPR
Gene ID: 2925
Primary Accession: P30550
NCBI Accession: NP_005305.1
Other Accession: P52500; P21729
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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